Software using 4ti2
CaTS http://www.soopadoopa.dk/anders/cats/cats.html
LattE integrale http://www.math.ucdavis.edu/~latte/
Frobby https://github.com/Macaulay2/frobby
Macaulay2 http://macaulay2.com/
Polymake http://www.polymake.org/
SageMath http://www.sagemath.org/
GAP GAP 4ti2 interface by Sebastian Gutsche
GAP package HeLP by Andreas Bächle, Leo Margolis